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Theoretical Modelling

By GlasgowUni 2011

During our project DISColi, regarding Bio-photolithography in biofilms, we created mathematical models involving T4 endolysin and its rate of diffusion through a biofilm. We are presenting our findings in Figure 1 and Table 1. Also, due to the mode of action of T4 Endolysin the attainable spatial resolution seems to be less than 0.01 mm. For more information, please visit GlasgowUni 2011 Wiki

Figure.1. Relative One-dimensional Diffusion of (a)T4 Endolysin at certain points in time and (b)T4 Endolysin within first 60 min. Threshold indicates critical concentration required for the molecule to work.

(a)

(b)

Table 1. Details on T4 Endolysin

Name of molecule	Length (a.a.)	Molecular weight (g/mol)	Diffusion rate (mm2/min)	Critical concentration (molecules)	Translation rate (molecule/min)	Achieving Critical Concentration (min)
T4 endolysin	164	18500	1.52*10-4	3000	57.2	52